Practice question from Cardiovascular Pharmacotherapy & Anticoagulation

Which DOAC is contraindicated in patients with mechanical heart valves and requires warfarin instead? A. Only dabigatran B. Only rivaroxaban C. Only apixaban D. All DOACs E. None, DOACs are preferred

Answer

D

Explanation

ALL DOACs are contraindicated in mechanical heart valve patients. The RE-ALIGN trial showed dabigatran increased thromboembolic events in mechanical valves. Warfarin remains the only option for these patients.

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